Science Writing and Rejection

Last week, I prepared my first manuscript for publication.  It was the first thing I've tried to publish based on my research.  We submitted it to Nature Medicine.  We got a response this week that the Editorial Board was rejecting it and was not sending it to the Review Board.  I know they reject a lot of papers and it's not personal, but I'm still a bit disappointed.  Round 2 will probably be the Journal of Clinical Investigation.  Hopefully that goes better!